In this study, information transfer of the interaction between the tropical Indian Ocean and global atmosphere is examined by using sea surface temperature and geopotential height based on the definition of source/sink information. Information transfer between the tropical Indian Ocean (20°S-20°N, 50°E-100°E) and atmosphere in the tropics, Northern Hemisphere, and Southern Hemisphere is analyzed, and regional characteristics are indicated. In addition, decadal changes and seasonal differences of information transfer between the tropical Indian Ocean and atmosphere are discussed. Essentially, the ocean information source is mainly in an area between 10°S-10°N and 60°E-90°E, and the atmosphere information sink is mainly in mid-latitude, zonal distribution in both hemispheres. The atmosphere information sink in the tropics is mainly in the lower troposphere. The distribution of source/sink information in the interaction between the tropical Indian Ocean and atmosphere in different seasons shows that the atmosphere response is stronger in the winter hemisphere to the tropical Indian. Accompanied by the interdecadal shift of the large-scale general circulation pattern in the late 1970s, the changes in information transfer between the tropical ocean and atmosphere in the Northern and Southern hemispheres are opposite, i.e., the Northern Hemisphere strengthens, and the Southern Hemisphere weakens.