It is still difficult for operational ocean models to accurately forecast meso- to micro-scale processes, such as the mesoscale ocean vortex. Therefore, the application of stable ocean model data is an effective method for ocean initialization in the regional typhoon-ocean coupled model. Using this method, the regional typhoon-ocean coupled model is applied to simulate two typhoon cases in this study. In addition, the effect of the radius of maximum wind speed (RMWS) on model simulation is investigated based on six sensitive experiments. Results show that the RMWS in typhoon initialization affects the simulation throughout the entire integration period. The larger the RMWS is, the more heat flux underneath is transported, which contributes to a stronger typhoon. Under the effect of strong typhoon winds, the ocean feedback effectively reduces the transportation of heat flux. Finally, this study emphasizes the importance of RMWS in characterizing typhoon intensity.