In this paper, the authors examined the sprite phenomenon over the southern Tibetan Plateau (22°-30°N, 86°-98°E) by comparing the lightning detection data from the World-Wide Lightning Location Network (WWLLN) and observations from the Imager of Sprites and Upper Atmospheric Lightning (ISUAL) instrument aboard the FORMOSAT-2 satellite during 2004-2015. It was found that most of the location accuracy of ISUAL was sound after analysis of 17 samples, and the deviations from WWLLN were ＜ 50 km. It was consistent with the results obtained in North America and its vicinity. Based on these results, the authors analyzed the characteristics of the parent lightning strokes of the sprites combined with the cloud-top brightness temperature data from the FY 2 satellite. The authors found that sprites over the southern Tibetan Plateau formed not only from mesoscale convective systems, but also from smaller-scale convective systems.