In the context of global warming, the Arctic region has warmed significantly and sea ice has retreated dramatically, and previous studies have revealed that the sea ice condition in the Barents Sea region in autumn is a significant precursor factor for temperature anomalies in Eurasia in late winter, while the activity of the low-level anticyclone in Siberia in winter is closely related to the change of the cold air, but whether and how the Arctic sea ice affects the activity of low-level anticyclone/cold high-pressure in winter in Siberia is still to be Further studies are needed. In this paper, the effects and pathways of low sea ice in autumn in the Barents Sea region on anticyclone activities in Siberia are investigated using the European Centre for Medium-Range Weather Forecasts (ECMWF) reanalysis data, ERA5, and sea ice data. The results show that: (1) the interannual variations of the fall sea-ice density in the Barents Sea region have an effect on both winter anticyclones and the quality of the cold air they carry in the Siberian region, and the anticyclone activity is enhanced and the cold air it carries is increased when there is less sea-ice in the fall. (2) Reduced sea ice area in the fall will lead to more ocean heat transfer to the atmosphere in the late season, thus reducing the meridional temperature gradient between the polar regions and the mid-latitudes in winter, and thus weakening the mid-latitude westerly winds, resulting in enhanced anticyclone activity in Eurasia. (3) Using the atmospheric circulation model CAM6, we designed a sensitivity test for sea ice changes in the Barents Sea region, and the results also reproduced that under conditions of low sea ice, most of the Eurasian continent, except for the area east of Lake Baikal and northeastern China, showed an increase in anticyclone frequency and an enhancement of the central pressure of the anticyclone. In particular, the reduction of sea ice caused a significant decrease in the meridional gradient of the vortex, which led to an increase in the frequency of blockages in the East European Plain, the Ural Mountains, and East Asia, resulting in an increase in anticyclone activity and a decrease in temperature in most of the mid-latitude regions of the Eurasian continent.