A regional climate model coupled with a chemistry-aerosol model (the ICTP RegCM3) is employed to simulate the anthropogenic aerosols including sulfate, black carbon and organic carbon and their direct effect on climate over Asia and China. The model is driven by the NCAR/NCEP re-analysis data. Multi-year simulations are conducted. Results show that the model performs well in reproducing present climate over the region. Simulation of the spatial and temporal patterns of aerosols is also reasonable although to a less extent. A greater latitudinal distribution of the aerosol concentration is simulated in winter compared to that in summer. Negative short wave radiative forcing is found at both the top of the atmosphere and the surface. The magnitude of the forcing is in good correspondence to the concentration of aerosols. The greatest concentration and largest radiative forcing are both found in the Sichuan Basin in Southwest China. Evident effects of the aerosols on both surface air temperature and precipitation are simulated over China. In winter, a drop in temperature impacted by aerosols is generally consistent with the aerosol concentration and distribution, whereas the largest decrease in temperature in summer is found in Hetao and the lower reaches of the Yellow River. The aerosol leads to a reduction of precipitation in eastern China both in winter and summer. The reasons for the temperature and precipitation changes are also presented in the paper.