The spatial and temporal distribution of lightning activity was examined in super typhoon Sepat in 2007, by using the data from the World Wide Lightning Location Network (WWLLN) and China Meteorological Administration (CMA). The results indicated that during the initial stage of typhoon, lightning near the centre was more active than that in outer rainbands. There were three lightning flash regions in the mature stage. During the dissipate stage, the lightning at the centre sharply decreased, and the lightning density in the outer rainband was much more than that at the centre. The evolution of eyewall lightning and total lightning tended to be episodic. Two eyewall lightning outbreaks occurred during the intensification of typhoon Sepat, and the second outbreak happened two hours prior to its maximum intensity, indicating that lightning activity might be used as a proxy of intensification of super typhoon. Eyewall replacement is indicative of typhoon intensity change and eyewall lightning change. Since the eyewall replacement, the flashes happening in the eyewall region was nearly zero. The flashes number was significantly correlated with the cloud top bright temperature. By combining the data of lightning imaging sensor (LIS) and TRMM Microwave Imager (TMI) aboard the Tropical Rainfall Measuring Mission (TRMM) satellite, it is found that lightning was most likely to occur in the deep convective systems with the polarized brightness temperature lower than 225 K. Lightning areas indicated by the WWLLN were similar to that by the TRMM-LIS.