A study of the interaction and mutual response between dynamical core and physical parameterizations by atmospheric general circulation models CAM3.1 and IAP AGCM4.0 is presented. Both the two models were integrated 60 d with ideal physics (Held-Suarez forcing) and with full physical package, respectively. The results show that the mutual responses between dynamical core and physical parameterizations are very different in the troposphere at low latitudes and high latitudes. In the tropical troposphere, the variability of temperature tendency due to dynamical core and that due to physical parameterizations are both large and have significant contributions to the variability of total temperature tendency, and they are in inverse correlation to compensate each other. In the polar middle and upper troposphere, the variability of total temperature tendency mainly relies on the tendency due to dynamical core, while the variation of temperature tendency due to physics is very slow, which can be seen as a stationary forcing. Unlike the tropical regions, there is a positive correlation between the temperature tendency due to dynamics and that due to physics in Polar regions. Moreover, the interactions and mutual responses between the individual physical parameterizations are also analyzed. The results show that the variation of temperature tendency due to moist process is the largest of all the physical parameterizations, and it contributes most to the total temperature tendency due to physics. The variation of temperature tendency due to long wave radiation is also large at high latitudes, while the variation of temperature tendency due to short wave radiation and that due to vertical diffusion are relatively small. There is a negative feedback between the cooling rate of long wave radiation and the heating rate of short wave radiation.